Try the brews San Francisco locals love at these top spots in the South of Market district.
ThirstyBear Organic Brewery
Start at ThirstyBear to begin your beer tour with a solid meal. The 10 beers on tap at the city's oldest brewpub—it's been around for 20 years—are all brewed specifically to accompany the tapas-inspired dishes on the menu. Try a kölsch with the calamares fritos or Tolstoy's Inkwell imperial stout with blue cheese-stuffed figs.
21st Amendment Brewery
21st Amendment is the largest and most well-known brewery on the list. (You've likely seen its watermelon wheat beer at restaurants across the Bay Area every summer.) At this former machine shop, choose from nearly a dozen beers on tap. Brews vary from a cider to a saison to a sour wheat. Once you've made your selection, beeline for the prime seating in the beer garden.
Black Hammer Brewing
Black Hammer serves small tasters of beer for just $4 each, so you don't have to commit to a full glass if you need a mid-tour break. The award-winning brewers of this craft brewery have created a great local, neighborhood space that welcomes beer drinkers, kids, and dogs alike.
Local Brewing Co.
One of the few female-run beer operations around, Local Brewing Co. aims to make approachable beers with flair. Try the "Bramble" nitro beer brewed with dark fruit or a pint of the "Ugly Winter Sweater," a barrel-aged dark sour beer. Whatever your pick, you're guaranteed to find the day's most unique brews at this small-batch brewery.
Cellarmaker Brewing Co.
End your day at Cellarmaker, where the laid-back vibe will make you feel right at home. Grab a pint, half-pint, or taster of any of the 10 or so experimental beers on tap. The selection is constantly changing, but don't worry—you can't really go wrong. The brewery also encourages guests to order food from neighborhood restaurants, like Goat Hill Pizza and CatHead's BBQ, to eat with its fresh brews. So sit back and enjoy dinner with a final brewsky: You've survived the SoMa brewery tour.